Lung CD200 Receptor Activation Abrogates Airway Hyperresponsiveness in Experimental Asthma

By Dr Deepu

The August issue of AJRCMB,study by Lauzon-Joset and colleagues demonstrate, in an experimental model of asthma, that local administration of CD200 inhibits airway hyperresponsiveness and lung accumulation of T helper type 2 cells, in addition to modulating the cytokine milieu within the lung. The authors note that "Given that airway hyperresponsiveness and inflammation are the root causes of asthma, these results pave the way to further investigations conducive to improved treatment."